Since hybrids cost more than "normal" cars with traditional gasoline engines, there's a hybrid price penalty that you should consider. In some cases this premium can be a few thousand dollars, but in others the price can be much higher. For example, the Nissan Altima hybrid and the normal Nissan Hybrid have a price difference of $6880. This means that, with gas currently at 2.64, you'd need to drive it for 22 years (we're not kidding) at a pace of 15,000 miles/year before you started recouping the cost benefit of the fuel mileage increase. Of course, if gas keeps edging up toward (and past) $4.00/gallon, your ability to recoup these costs is closer within reach.
Lesson learned: Hybrids make more financial sense when gas is more expensive.